FAST TRACK HAMLET (human a-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death
نویسندگان
چکیده
Sonja Aits, Lotta Gustafsson, Oskar Hallgren, Patrick Brest, Mattias Gustafsson, Maria Trulsson, Ann-Kristin Mossberg, Hans-Uwe Simon, Baharia Mograbi and Catharina Svanborg* Institute of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden Department for Experimental Medical Sciences, Section for Lung Biology, Lund University, Lund, Sweden INSERM ERI 21/EA 4319 ‘‘Inflammation and Carcinogenesis’’, Faculty of Medicine, University of Nice-Sophia Antipolis, Nice, France Department of Pharmacology, University of Bern, Bern, Switzerland Singapore Immunology Network (SIgN), Biomedical Sciences Institutes, Agency for Science, Technology, and Research (A*STAR), IMMUNOS, BIOPOLIS, Singapore
منابع مشابه
Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET.
Histone deacetylase inhibitors (HDIs) and HAMLET (human alpha-lactalbumin made lethal to tumor cells) interact with histones, modify the structure of chromatin, and trigger tumor cell death. This study investigated how the combination of HDIs and HAMLET influences cell viability, histone acetylation, and DNA integrity. The pretreatment of tumor cells with HDIs was shown to enhance the lethal ef...
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HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is the first member in a new family of protein-lipid complexes with broad tumoricidal activity. Elucidating the molecular structure and the domains crucial for HAMLET formation is fundamental for understanding its tumoricidal function. Here we present the low-resolution solution structure of the complex of oleic acid bound HAMLET, deri...
متن کاملMolecular mechanisms of the cytotoxicity of human α-lactalbumin made lethal to tumor cells (HAMLET) and other protein-oleic acid complexes.
Although HAMLET (human α-lactalbumin made lethal to tumor cells), a complex formed by human α-lactalbumin and oleic acid, has a unique apoptotic activity for the selective killing of tumor cells, the molecular mechanisms of expression of the HAMLET activity are not well understood. Therefore, we studied the molecular properties of HAMLET and its goat counterpart, GAMLET (goat α-lactalbumin made...
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In human milk α-lactalbumin is one of the main proteins which harbors tumor-selective capabilities, named human α-lactalbumin made lethal to tumor cells (HAMLET). HAMLET is formed by binding of α-lactalbumin with oleic acid resulting in release of its Ca2+ ion and a folding change. It induces apoptosis in tumor cells but leaves normal differentiated cells unaffected. It has the capability to en...
متن کاملHAMLET: functional properties and therapeutic potential.
Human α-lactalbumin made lethal to tumor cells (HAMLET) is the first member in a new family of protein-lipid complexes that kills tumor cells with high selectivity. The protein component of HAMLET is α-lactalbumin, which in its native state acts as a substrate specifier in the lactose synthase complex, thereby defining a function essential for the survival of lactating mammals. In addition, α-l...
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